Alteration of Transcriptomic Networks in Adoptive-Transfer Experimental Autoimmune Encephalomyelitis

Modifier-Binding Domain Peptides in the Adoptive Transfer Model of Experimental Allergic Encephalomyelitis

Experimental autoimmune encephalomyelitis in the mouse.

This unit details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP). Detailed materials and methods required for the purification of both PLP and MBP are also des...

Autoimmune Encephalomyelitis Adoptive Transfer Experimental in the Pathogenesis of Both Acute and Phosphatidylserine and Oxidized Lipoprotein 16/Scavenger Receptor that Binds Critical Roles of CXC Chemokine Ligand

Suppression of experimental autoimmune encephalomyelitis by intravenously administered polyclonal immunoglobulins.

Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats either by active immunization with myelin basic protein (MBP) or by adoptive transfer using anti-MBP specific CD4(+)T cells. Treatment with human polyclonal immunoglobulins (IgG) effectively suppressed active EAE. Time-dependent experiments demonstrated that the effect of IgG was manifested only when treatment was given i...

Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element

The adoptive transfer of clinical and histopathologic signs of experimental allergic encephalomyelitis (EAE) requires MHC compatibility between cell donor and cell recipient. The results of adoptive transfer studies using F1 to parent bone marrow chimeras as recipients of parental-derived BP-sensitive spleen cells indicate that this restriction is not expressed at the level of the endothelial c...